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KMID : 1143820200160020106
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Anxiety and Mood
2020 Volume.16 No. 2 p.106 ~ p.112
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The Uncinate Fasciculus Sub-Tract Connecting Face-Specific Regions in Patients with Social Anxiety Disorder : A Preliminary Study
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Kang Bong-Suk
Lee Yoon-Ji Irene
Lee Jae-Yeon
Choi Soo-Hee
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Abstract
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Objective : Social anxiety disorder (SAD) is characterized by fear of social threat and exhibits limbichyper-reactivity toward social stimuli such as emotional faces. A previous study identified the uncinate fasciculus(UF) sub-tract as particularly related to facial memory. To explore the white matter tract relating toface-specific brain regions, we investigated the UF sub-tract in SAD.
Methods : The diffusion tensor images of 22 patients with SAD and 20 healthy controls were analyzedwith tractography. The UF sub-tract was delineated using the regions of interest of face patches in the anteriortemporal lobe and the orbitofrontal cortex, and fractional anisotrophy (FA) and total number of streamlines(ST) were analyzed. We examined the group comparison of FA and ST of the UF sub-tract and correlationsof FA and ST with the social anxiety symptoms such as the Liebowitz Social Anxiety Scale (LSAS),the Social Interaction Anxiety Scale (SIAS), the Social Phobia Scale (SPS) and the Fear of Negative Evaluationscale (FNE) in SAD.
Results : There were no group differences in FA and ST of the UF sub-tract. However, negative correlationswere observed between ST of the right UF sub-tract and severity of social anxiety symptoms (LSAS, rs=-0.480, p=0.024; SIAS, rs=-0.580, p=0.005; SPS, rs=-0.590, p=0.004; FNE, rs=-0.675, p=0.001) in patientswith SAD.
Conclusion : Although patients with SAD did not show quantitative abnormalities in the UF sub-tact connectingface-specific brain regions, this structure seems to play a role in the symptom severity of SAD.
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KEYWORD
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Uncinate fasciculus, Social anxiety disorder, White matter sub-tract·Diffusion tensor imaging
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